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St. John's Wort Extract

St. John

Extract Name: St. John's Wort Extract

Abbr. Name: John's wort extract

Extract Category: Herbal Extract

Extract Class: Herbal Extracts

St. John's Wort Extract Detail:

St. John's Wort Extract--John's wort extract
Latin Name---Herb Hyperici Perforati.
Appearance---Brown Powder
Test Method---UV
Part of the Plant Used---The whole grass wounded in action of Hypericum Perforatum
Extract Method---Normal extraction(Ethanol&Water extraction) 
Applicable field---Medical trade, Health product trade, antioxidant
Assay---Hypericin 0.3% Naringin 98%
Heavy Meta---<10ppm
Total Plate Count---<1000cfu/g
Yeast & Mold---<100cfu/g
Loss on Drying---<2%
E. Coli---Negative
Pesticides--- Negative
Active material---Hypericin Naringin
Molecular Formula---C30H16O8
Molecular Weight---504.43
Melting point---79-80C
Packing---5 kilograms/ Aluminium foil bag 25 kilograms/ Cardboard barrel
Particle size---90% pass 80 mesh
Shelf Life---24-36 Months

St. John's Wort has a complex and diverse chemical make-up. Hypericin and pseudohypericin are believed to have antidepressive and antiviral properties. Other constituents, such as xanthones and flavonoids, may also contribute to the medicinal actions of St. John's Wort. The following are the active constituents:

Essential oil, containing caryophyllene, methyl-2-octane, n-nonane, n-octanal, n-decanal, a- and b-pinene, and traces of limonene and myrcene
Hypericins, prenylated phloroglucin derivatives; hypericin, pseudohypericin and hyperforin
Miscellaneous; flavonoids, () and (-) - epicatechin.
Hypericum extract contains numerous active compounds that together create the antidepressant and antianxiety effects. Hypericum is the first known substance to enhance three key neurotransmitters- serotonin, norepinephrine, and dopamine. Preliminary research suggests that St. John's Wort also lowers levels of the stress hormone cortisol and enhances the activity of gamma-aminobutyric acid (GABA), a naturally occurring tranquilizer in the brain. It is a very mild, clinically insignificant monoamine oxidase (MAO) inhibitor. 

The mechanism by which St. John's Wort acts as an antidepressant is not fully understood. Early research indicated that this herb mildly inhibits the enzyme monoamine oxidase (MAO). MAO is responsible for the breakdown of two brain chemicals - serotonin and norepinephrine. By inhibiting MAO and increasing norepinephrine, St. John's Wort may exert a mild antidepressive action. The antidepressant or mood elevating effects of St. John's Wort were originally thought to be due solely to hypericin, but hypericin does not act alone. St. John's Wort relies on the complex interplay of many constituents such as xanthones and flavonoids for its antidepressant actions. St. John's Wort may also block the receptors that bind serotonin.

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